abstract：:Thrombolytic therapy provides clinical benefit in patients with vascular occlusions, depending upon the organ or limb that is threatened. The impact of therapeutic intervention varies from the quiet alteration of the course of deep vein thrombosis, for which non-life threatening post-phlebitic syndrome can be largely ...

journal_title：Thrombosis and haemostasis

authors： Marder VJ

更新日期：1995-07-01 00:00:00

abstract：:The characterization of mutations in von Willebrand disease provides useful insight into the synthesis, structure, and function of von Willebrand factor. This growing body of information has prompted a reclassification of vWD types that is intended to reflect distinct pathophysiologic mechanisms. Despite this apparent...

journal_title：Thrombosis and haemostasis

authors： Sadler JE,Matsushita T,Dong Z,Tuley EA,Westfield LA

更新日期：1995-07-01 00:00:00

abstract：:Platelet activation as a result of vascular injury provokes endothelial cells to respond in a manner which limits or reverses the occlusive consequences of platelet accumulation. If the agonistic forces are strong, platelet accumulation is irreversible. In vitro data from our laboratory have repeatedly demonstrated th...

journal_title：Thrombosis and haemostasis

authors： Marcus AJ,Safier LB,Broekman MJ,Islam N,Fliessbach JH,Hajjar KA,Kaminski WE,Jendraschak E,Silverstein RL,von Schacky C

更新日期：1995-07-01 00:00:00

abstract：:Antiphospholipid-protein antibodies (APA) are a family of immunoglobulins which have been defined by varying laboratory test systems. Lupus anticoagulants (LA) and anticardiolipin antibodies (ACA) are the two most prominent members of this family of antibodies. LA are detected utilizing various phospholipid (PL) depen...

journal_title：Thrombosis and haemostasis

authors： Triplett DA

更新日期：1995-07-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein however the mechanisms by which Lp(a) promote the atherosclerotic process are not clear. The apolipoprotein(a) portion of Lp(a) shares partial homology with plasminogen, a finding that has stimulated numerous studies. Lp(a) binds to fibrin and the affinity between f...

journal_title：Thrombosis and haemostasis

authors： Harpel PC,Hermann A,Zhang X,Ostfeld I,Borth W

更新日期：1995-07-01 00:00:00

abstract：:A possible role of the plasminogen/plasmin or fibrinolytic system in several biological processes has been implied from correlations between fibrinolytic activity and (patho)physiological phenomena. However, such indirect evidence does not allow to definitively establish the biological relevance of this system. Two re...

journal_title：Thrombosis and haemostasis

authors： Carmeliet P,Collen D

更新日期：1995-07-01 00:00:00

abstract：:Fibrin sealant use in the United States has been limited because of the lack of a commercially available, government approved product. However, the significant need and usefulness of this material at the time of surgical operations has stimulated alternative sources of production. At the University of Virginia, the Bl...

journal_title：Thrombosis and haemostasis

authors： Spotnitz WD

更新日期：1995-07-01 00:00:00

abstract：:Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal module...

journal_title：Thrombosis and haemostasis

authors： Mosher DF

更新日期：1995-07-01 00:00:00

abstract：:Over the last few years methods have been developed to assess appearance of thrombin during blood clotting in a clinical setting. This can be achieved either by measurement of the specific thrombin markers or by analysis of the thrombin generation kinetics. Thrombin markers rise following coronary occlusion and, surpr...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A

更新日期：1995-07-01 00:00:00

abstract：:We investigated plasma activated factor VII (FVIIa) levels in uremic patients (nondialysis group: n = 38; dialysis group: n = 36) and healthy controls (n = 32). We also measured the plasma levels of thrombomodulin (an indicator of endothelial cell injury) and tissue factor. Plasma FVIIa showed a marked increase in the...

journal_title：Thrombosis and haemostasis

authors： Kario K,Matsuo T,Matsuo M,Koide M,Yamada T,Nakamura S,Sakata T,Kato H,Miyata T

更新日期：1995-05-01 00:00:00

abstract：:Intraoperative high-dose aprotinin administration has been shown to reduce the intra-and postoperative blood loss in cardiac surgery. The haemostatic effect has been attributed to platelet preserving properties and to inhibition of contact activation reducing thrombotic and fibrinolytic activity during and after cardi...

journal_title：Thrombosis and haemostasis

authors： Spannagl M,Dooijewaard G,Dietrich W,Kluft C

更新日期：1995-05-01 00:00:00

abstract：:Glucose intolerance, hyperinsulinaemia, dyslipoproteinaemia and multiple disturbances of haemostatic function are characteristics of young men with premature coronary artery disease. The relations between glucose, insulin and insulin propeptides, in the fasting state, and after an oral glucose load, and haemostatic fu...

journal_title：Thrombosis and haemostasis

authors： Båvenholm P,Proudler A,Silveira A,Crook D,Blombäck M,de Faire U,Hamsten A

更新日期：1995-04-01 00:00:00

abstract：:To investigate pituitary effects on the vitamin K-dependent coagulation factors, female rats were hypophysectomized (hypox) and treated with growth hormone (GH), cortisone, thyroxine, vitamin K, or saline. After 11 days of treatment, the prothrombin time, platelet count, and factors II, VII, IX, and X were determined....

journal_title：Thrombosis and haemostasis

authors： Sävendahl LS,Grankvist K,Engström KG

更新日期：1995-04-01 00:00:00

abstract：:We found that intracellular Ca2+ concentration ([Ca2+]i) increased during ristocetin-induced agglutination of aequorin loaded platelets resuspended in plasma. Chelation of extracellular Ca2+ had no effect on platelet clumping, but delayed and greatly reduced Ca2+ increase, indicating that it derived for the most part ...

journal_title：Thrombosis and haemostasis

authors： Bertolino G,Noris P,Spedini P,Balduini CL

更新日期：1995-04-01 00:00:00

abstract：:Fibrinolytic therapy can result in rapid lysis of deep vein thrombi (DVT), but its use is limited by the failure of many patients to respond and by the increased risk of bleeding complications in comparison with anticoagulant therapy alone. Treatment could be improved by the ability to select patients most likely to r...

journal_title：Thrombosis and haemostasis

authors： Francis CW,Totterman S

更新日期：1995-03-01 00:00:00

abstract：:An enzyme immuno assay was developed to measure complexes of tissue-type plasminogen activator (t-PA) with C1-inhibitor in order to study the role of C1-inhibitor as an inhibitor of t-PA in plasma. In vitro experiments with melanoma and recombinant t-PA learned that purified C1-inhibitor reacts with both single chain ...

journal_title：Thrombosis and haemostasis

authors： Huisman LG,van Griensven JM,Kluft C

更新日期：1995-03-01 00:00:00

abstract：:To study the effect of lymphocyte adhesion on the procoagulant activity of endothelial cells, we have stimulated HUVECs with interferon-gamma to upregulate adhesion molecules. Subsequent addition of lymphocytes induced the expression of tissue factor (TF) by HUVECs. Both CD4+ and CD8+ T-cells promoted this TF synthesi...

journal_title：Thrombosis and haemostasis

authors： Schmid E,Müller TH,Budzinski RM,Pfizenmaier K,Binder K

更新日期：1995-03-01 00:00:00

abstract：:We have identified a patient with a dysfunctional prothrombin that we have designated Prothrombin Frankfurt. The proband was characterized by a prothrombin activity level of 13% and 20% compared to normal controls using two different assays with a normal prothrombin antigen level of 91% of normal controls. The genetic...

journal_title：Thrombosis and haemostasis

authors： Degen SJ,McDowell SA,Sparks LM,Scharrer I

更新日期：1995-02-01 00:00:00

abstract：:We have recently reported the short-term intraindividual variability of several coagulation factors and inhibitors included in the ARIC study (Chambless et al. Ann Epidemiol 1992; 2:723). In this paper, we reported the intraindividual variability results of additional hemostatic factors. Blood samples were collected f...

journal_title：Thrombosis and haemostasis

authors： Nguyen ND,Ghaddar H,Stinson V,Chambless LE,Wu KK

更新日期：1995-02-01 00:00:00

abstract：:We reported previously that plasma fibrinogen was significantly higher in U.S. Caucasians than in Japanese, which may contribute to the higher mortality rate of coronary heart disease in the United States than in Japan. To examine the contribution of genetic variations to the race difference in plasma fibrinogen level...

journal_title：Thrombosis and haemostasis

authors： Iso H,Folsom AR,Winkelmann JC,Koike K,Harada S,Greenberg B,Sato S,Shimamoto T,Iida M,Komachi Y

更新日期：1995-01-01 00:00:00

abstract：:In an international collaborative study three candidate reference and the local APTT reagent have been tested with lyophilized plasmas containing heparin added in vitro and fresh plasmas from heparinized patients to determine whether it was possible to standardize APTT heparin monitoring. The APTT responses of patient...

journal_title：Thrombosis and haemostasis

authors： Van der Velde EA,Poller L

更新日期：1995-01-01 00:00:00

abstract：:The clinical benefits of unfractionated heparin (UFH) and low molecular weight heparin (LMWH) have been shown in many trials. However, the mode of action of heparin has not been fully elucidated. Thus, we wanted to study the effects of UFH and LMWH in vivo by measuring coagulation activation markers in blood obtained ...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Wolz M,Nieszpaur-Los M,Schneider B,Lechner K,Eichler HG,Kyrle PA

更新日期：1994-12-01 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is a fibrin-specific agent which is used to treat acute myocardial infarction. Pharmacokinetically, t-PA is characterized by a rapid clearance from the circulation. In a previous study, we constructed variant forms of t-PA with genetic modifications at the fibronectin finger-li...

journal_title：Thrombosis and haemostasis

authors： Yahara H,Matsumoto K,Maruyama H,Nagaoka T,Ikenaka Y,Yajima K,Fukao H,Ueshima S,Matsuo O

更新日期：1994-12-01 00:00:00

abstract：:Previous studies have reported that the platelets of healthy term neonates have either diminished or normal reactivity compared to the platelets of adults. To circumvent the methodologic problems of previous studies, we used a whole blood flow cytometric method to study neonatal platelet reactivity to thrombin, a comb...

journal_title：Thrombosis and haemostasis

authors： Rajasekhar D,Kestin AS,Bednarek FJ,Ellis PA,Barnard MR,Michelson AD

更新日期：1994-12-01 00:00:00

abstract：:Plasma levels of D-dimer have been found useful as a marker of deep venous thrombosis in those patients in whom thrombosis is suspected, but their usefulness in postoperative screening is less clear. We have investigated the relationship of D-dimer to deep venous thrombosis in 90 patients after total hip and knee arth...

journal_title：Thrombosis and haemostasis

authors： Dunn ID,Hui AC,Triffitt PD,Crozier AE,Gregg PJ,Sinclair ME,Armstrong AL,Mitchell VE

更新日期：1994-11-01 00:00:00

abstract：:It is known that lupus anticoagulants (LA) are antibodies which interfere with phospholipid-dependent coagulation tests, but due to the heterogeneity of LA and the differences in sensitivity of reagents and tests, the diagnosis of LA remains difficult. Recently, Triplett et al. (26) have proposed a new test based on t...

journal_title：Thrombosis and haemostasis

authors： Forastiero RR,Cerrato GS,Carreras LO

更新日期：1994-11-01 00:00:00

abstract：:We performed a prospective study in 86 consecutive patients with central vein catheter-related deep venous thrombosis (DVT) of the upper extremity, to evaluate the prevalence of pulmonary embolism (PE), and to identify clinical variables that would increase the likelihood of developing PE in an individual patient. Sin...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Raventos A,Lerma R,Ruiz J,Lafoz E,Alastrue A,Llamazares JF

更新日期：1994-10-01 00:00:00

abstract：:The influence of storage of platelet concentrates (PC) on the adhesion capacity of platelets was studied. Twenty-four PC, 12 prepared by the buffy coat (BC) method and 12 by the platelet-rich plasma (PRP) method, were stored for 7 days at room temperature. On days 1, 3 and 7 of storage, the platelet adhesion capacity ...

journal_title：Thrombosis and haemostasis

authors： Boomgaard MN,Gouwerok CW,Homburg CH,de Groot G,IJsseldijk MJ,de Korte D

更新日期：1994-10-01 00:00:00

abstract：:Recent meta-analyses indicate that low molecular weight heparins (LMWH) are more effective than unfractionated heparin (UH) in preventing and treating deep vein thrombosis. This article presents the arguments for and against the need for laboratory monitoring. At the present time, the only tests currently available fo...

journal_title：Thrombosis and haemostasis

authors： Boneu B

更新日期：1994-09-01 00:00:00

abstract：:We investigated the protective effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against two kinds of experimental disseminated intravascular coagulation (DIC) in rats. Endotoxin-induced experimental DIC was induced by a 4-h sustained infusion of endotoxin at a dose of 100 m...

journal_title：Thrombosis and haemostasis

authors： Yamazaki M,Asakura H,Aoshima K,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Ikeda T,Matsuda T

更新日期：1994-09-01 00:00:00

abstract：:To evaluate the role of low-molecular weight heparin (LMWH) as an alternative to oral anticoagulants in the prevention of recurrent venous thromboembolism, we compared in a randomized trial conventional warfarin treatment with a three-month course of enoxaparin 4000 anti-Xa units once a day subcutaneously. 187 patient...

journal_title：Thrombosis and haemostasis

authors： Pini M,Aiello S,Manotti C,Pattacini C,Quintavalla R,Poli T,Tagliaferri A,Dettori AG

更新日期：1994-08-01 00:00:00

abstract：:Haemorrhagic metalloproteinases from Bothrops jararaca and other venoms degrade vessel-wall and plasma proteins involved in platelet plug and fibrin clot formation. These enzymes also cause proteolytic digestion of fibrinogen which has been suggested to cause defective platelet function. Fibrinogen degradation by jara...

journal_title：Thrombosis and haemostasis

authors： Kamiguti AS,Slupsky JR,Zuzel M,Hay CR

更新日期：1994-08-01 00:00:00

abstract：:The in vitro effect of nifedipine, a calcium channel blocker of the dihydropyridine (DHP) type, on platelet aggregation was reinvestigated considering especially the capability of platelets to form endogenous nitric oxide (NO). We studied the dose-dependent antiaggregatory property of nifedipine in porcine platelet ri...

journal_title：Thrombosis and haemostasis

authors： Berkels R,Klaus W,Boller M,Rösen R

更新日期：1994-08-01 00:00:00

abstract：:Multifunctional proteins, e.g. high molecular weight kininogen (HK, 120 kDa) and the homotrimer, thrombospondin (TSP, 540 kDa), which have more than one domain on a single polypeptide chain, are particularly well-suited to be structural elements of extracellular matrices because of their ability to bind to several mac...

journal_title：Thrombosis and haemostasis

authors： DeLa Cadena RA,Wyshock EG,Kunapuli SP,Schultze RL,Miller M,Walz DA,Colman RW

更新日期：1994-07-01 00:00:00

abstract：:We determined factor VII antigen (FVIIag) levels in 705 healthy blood donors ranging in age from 17 to 79 years using a two-site solid-phase enzyme immunoassay developed in our laboratory. The mean (+/- SD) FVIIag level for the total population was 102 +/- 31%. FVIIag levels for men (n = 375) and women (n = 330) were ...

journal_title：Thrombosis and haemostasis

authors： Howard PR,Bovill EG,Pike J,Church WR,Tracy RP

更新日期：1994-07-01 00:00:00

abstract：:A technique has been developed to monitor the development of thrombin in freshly collected whole blood in the absence of anticoagulants. It is based on the centrifugal separation of the cellular components from subsamples of blood drawn from non-anticoagulated clotting whole blood which are diluted in buffer containin...

journal_title：Thrombosis and haemostasis

authors： Kessels H,Béguin S,Andree H,Hemker HC

更新日期：1994-07-01 00:00:00

abstract：:To identify whether genotype contributes to the difference in PAI-1 levels in type 1 and type 2 diabetic subjects and whether genotype relates to the development of retinopathy, a Hind III restriction fragment length polymorphism and two dinucleotide repeat polymorphisms were studied. In 519 Caucasian diabetic subject...

journal_title：Thrombosis and haemostasis

authors： Mansfield MW,Stickland MH,Carter AM,Grant PJ

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Recombinant hirudin, a pure, specific antithrombin could be more effective than heparin in the treatment of deep vein thrombosis, but its short half-life requires constant intravenous infusion, whereas subcutaneous administration of recombinant hirudin can ensure stable and prolonged plasma levels. The aim o...

journal_title：Thrombosis and haemostasis

authors： Schiele F,Vuillemenot A,Kramarz P,Kieffer Y,Soria J,Soria C,Camez A,Mirshahi MC,Bassand JP

更新日期：1994-05-01 00:00:00

abstract：:Transient procoagulant states resulting in failure of recanalization or rethrombosis of the reperfused artery during thrombolytic therapy might be due to an inhibitory effect of plasmin on the anticoagulant properties of protein C. We therefore studied the effect of plasmin on protein C (PC) and activated protein C (A...

journal_title：Thrombosis and haemostasis

authors： Váradi K,Philapitsch A,Santa T,Schwarz HP

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Prospective studies on the incidence of thrombosis in asymptomatic individuals with hereditary protein C- or protein S deficiency have not been performed so far. OBJECTIVE:We have carried out a prospective cohort study in 44 asymptomatic protein C- and protein S deficient subjects and in 49 asymptomatic non...

journal_title：Thrombosis and haemostasis

authors： Pabinger I,Kyrle PA,Heistinger M,Eichinger S,Wittmann E,Lechner K

更新日期：1994-04-01 00:00:00